An object containing the estimates produced using the multivariable MR-Egger method as well as various statistics.
Slots
ModelModel always takes the value
random, as only random-effects analyses are permitted.OrientateThe number of the risk factor that genetic associations are orientated to. The default value is
1, meaning that genetic associations with the first risk factor are set to be positive.ExposureThe names of the exposure variables.
OutcomeThe name of the outcome variable.
CorrelationThe matrix of correlations between genetic variants.
EstimateThe causal estimates from the inverse-variance weighted method.
StdError.EstThe standard errors associated with
Estimate.CILower.EstThe lower bounds of the confidence interval for
Estimatebased onStdError.CIUpper.EstThe upper bounds of the confidence interval for
Estimatebased onStdError.Pvalue.EstP-value associated with the causal estimate.
InterceptThe intercept estimate from the MR-Egger method. Under the InSIDE assumption, the intercept represents the average pleiotropic effect (average direct effect on the outcome) of a genetic variant. If the intercept differs from zero, this is evidence that the genetic variants are not all valid instruments; specifically, there is directional pleiotropy.
StdError.IntThe standard error associated with
Intercept.CILower.IntThe lower bound of the confidence interval for
Interceptbased onStdError.Int.CIUpper.IntThe upper bound of the confidence interval for
Estimatebased onStdError.Int.Pvalue.IntP-value associated with the intercept.
AlphaThe significance level used in constructing the confidence interval (default is 0.05).
SNPsThe number of SNPs that were used in the calculation.
RSEThe estimated residual standard error from the regression model.
Heter.StatHeterogeneity statistic (Cochran's Q statistic) and associated p-value: the null hypothesis is that all genetic variants estimate the same causal parameter; rejection of the null is an indication that one or more variants may be pleiotropic.