Function reference • MendelianRandomization

Data input functions

mr_input(): Inputting and formatting data for use in causal estimation

mr_mvinput(): Inputting and formatting data for use in causal estimation

phenoscanner(): PhenoScanner

pheno_input(): Extract summarized data from PhenoScanner

Univariable methods

mr_allmethods(): Mendelian randomization estimation using all methods

mr_cML(): Constrained maximum likelihood (cML) method

mr_conmix(): Contamination mixture method

mr_divw(): Debiased inverse-variance weighted method

mr_egger(): MR-Egger method

mr_ivw(): Inverse-variance weighted method

mr_hetpen(): Heterogeneity-penalized method

mr_lasso(): MR-Lasso method

mr_maxlik(): Maximum-likelihood method

mr_mbe(): Mode-based method of Hartwig

mr_median(): Median-based method

mr_pcgmm(): Univariable principal components generalized method of moments (PC-GMM) method

mr_pivw(): Penalized inverse-variance weighted method

mr_clr(): Conditional likelihood ratio (CLR) method

Multivariable methods

mr_mvivw(): Multivariable inverse-variance weighted method

mr_mvlasso(): Multivariable MR-Lasso method

mr_mvmedian(): Multivariable median-based method

mr_mvcML(): Multivariable constrained maximum likelihood method

mr_mvegger(): Multivariable MR-Egger method

mr_mvgmm(): Multivariable generalized method of moments (GMM) method

mr_mvpcgmm(): Multivariable principal components generalized method of moments (PC-GMM) method

mr_mvivwme(): Multivariable inverse-variance weighted method with measurement error

Graphical functions

mr_plot(): Draw a scatter plot of the genetic associations and/or causal estimates

mr_forest(): Draw a forest plot of causal estimates

mr_funnel(): Draw a funnel plot of variant-specific estimates

mr_loo(): Leave-one-out estimates

Example datasets

calcium calciumse fastgluc fastglucse calc.rho: Data on effect of calcium on fasting glucose (correlated variants)

ldlc hdlc hdlcse ldlcse trig trigse chdlodds chdloddsse lipid_effect lipid_other lipid_eaf: Data on lipid effects on coronary artery disease (uncorrelated variants)

Output descriptions

DIVW-class: DIVW Class

Egger-class: Egger Class

IVW-class: IVW Class

MaxLik-class: MaxLik Class

MRAll-class: MRAll Class

MRcML-class: MRcML Class

MRConMix-class: MRConMix Class

MRHetPen-class: MRHetPen Class

MRInput-class: MRInput Class

MRLasso-class: MRLasso class

MRMBE-class: MRMBE Class

MRMVInput-class: MRMVInput Class

MVEgger-class: MVEgger Class

MVGMM-class: MVGMM Class

MVIVW-class: MVIVW Class

MVLasso-class: MRMVLasso class

MVMedian-class: MRMVMedian class

MVMRcML-class: MVMRcML Class

PIVW-class: PIVW Class

WeightedMedian-class: WeightedMedian Class

MVPCGMM-class: MVPCGMM Class

PCGMM-class: PCGMM Class

MVIVWME-class: MVIVWME Class

CLR-class: CLR Class