PCGMM Class — PCGMM-class • MendelianRandomization

An object containing the estimates produced using the univariable principal components generalized method of methods (PC-GMM) method as well as various statistics.

Slots

robust: Whether the robust model with overdispersion heterogeneity is estimated.
Exposure: The name of the exposure variable.
Outcome: The name of the outcome variable.
Correlation: The matrix of correlations between genetic variants.
Estimate: The causal estimate from the PC-GMM method.
StdError: The standard error associated with Estimate.
CILower: The lower bound of the confidence interval for Estimate based on StdError.
CIUpper: The upper bound of the confidence interval for Estimate based on StdError.
Fstat: The first-stage F statistic for all genetic principal components used as instruments.
Overdispersion: The estimate of the overdispersion parameter for the robust model.
PCs: The number of genetic principal components used to instrument the exposure.
Pvalue: P-value associated with the causal estimate.
Alpha: The significance level used in constructing the confidence interval (default is 0.05).
Heter.Stat: Heterogeneity statistic (Cochran's Q statistic) and associated p-value (for non-robust model): the null hypothesis is that all principal components estimate the same causal parameter; rejection of the null is an indication that one or more principal components may be pleiotropic.